2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118820
    MB-28767
    		Agonist
    MB-28767 (M&B 28767) is an EP3 receptor agonist.
    MB-28767
  • HY-137355
    15(S)-15-methyl Prostaglandin D2
    15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).
    15(S)-15-methyl Prostaglandin D2
  • HY-163552
    Prostaglandin F2a/BSA
    Prostaglandin F2a/BSA is an antigen-adjuvant conjugate formed by the conjugation of Prostaglandin F2a with Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes and can enhance cross-presentation as well as the generation of antigen-specific T cells.
    Prostaglandin F2a/BSA
  • HY-136627
    PGF2α analogue-1
    PGF2α analogue-1 is an analog of Dinoprost (HY-12956) containing an acetylenic fluorobenzene substituent in the lower side chain.
    PGF2α analogue-1
  • HY-119890
    Isbogrel
    Isbogrel (CV-4151) is a potent selective inhibitor of thromboxane A2 synthase. Isbogrel has oral activity and inhibits blood TXA2 generation with an ID50 value of 0.04 mg/kg.
    Isbogrel
  • HY-106534
    Gemeprost
    Gemeprost (Preglandin), a Prostaglandin E1 (HY-B0131) analogue, is a potent antiprogestogen drug. Gemeprost has the potential for second trimester abortion research.
    Gemeprost
  • HY-120123
    FR181157
    		Agonist
    FR181157, an orally active PGI2 agonist activity with especially good pharmacokinetic properties.
    FR181157
  • HY-170610
    mPGES-1/sEH-IN-1
    mPGES-1/sEH-IN-1 (compound 1f) is an inhibitor of sEH with IC50 value of 5 μM. mPGES-1/sEH-IN-1 shows antitumor activity with IC50 value of 25 µM via inhibts mPGES‐1.
    mPGES-1/sEH-IN-1
  • HY-118728
    Prostaglandin A2 methyl ester
    		Control
    Prostaglandin A2 methyl ester (PGA2 methyl ester) is a methylated derivative of the prostaglandin PGA2 (HY-113041).
    Prostaglandin A2 methyl ester
  • HY-149290
    AMX12006
    		Antagonist
    AMX12006 is a potent, selective and orally active EP4 antagonist with an IC50 value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity.
    AMX12006
  • HY-126081
    (8-epi)-BW 245C
    		Agonist
    (8-epi)-BW 245C is the C-8 diastereomer of BW 245C (HY-101987). BW 245 C is a high affinity and selective PGD2 receptor agonist.
    (8-epi)-BW 245C
  • HY-18970
    TG6-129
    		Antagonist
    TG6-129 is a selective antagonist of the EP2 receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages.
    TG6-129
  • HY-131617
    Prostaglandin F2α 1,11-lactone
    		Control
    Prostaglandin F2α 1,11-lactone is a prostaglandin. Prostaglandin F2α 1,11-lactone is absorbed by the eye. Prostaglandin F2α 1, 11-Lactone has metabolic stability on the corneal surface and conjunctiva. Prostaglandin F2α 1,11-lactone can be used in the treatment of glaucoma .
    Prostaglandin F2α 1,11-lactone
  • HY-118556
    Prostaglandin E2 serinol amide
    		Agonist
    Prostaglandin E2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol. Prostaglandin E2 serinol amide is non-hydrolyzable to produce PGE2 and thus cannot inhibit leukotriene B4 biosynthesis, superoxide production, migration and antimicrobial peptide release.
    Prostaglandin E2 serinol amide
  • HY-114793
    AL-12180
    		Agonist
    AL-12180 is a potent and selective FP-receptor agonist with a Ki of 143 nM. AL-12180 stimulates the mobilization of intracellular Ca2+ in h-TM and h-CM cells with EC50s of 111 and 11 nM, respectively.
    AL-12180
  • HY-105953
    Froxiprost
    Froxiprost (ONO-995) is a PGF2α (HY-12956) analogue. Froxiprost stimulates thymidine uptake, 1,2 diacylglycerol (1,2-DAG) accumulation, and phosphorylcholine formation in osteoblast-like MC3T3-E1 cells.
    Froxiprost
  • HY-129786
    LG 82-4-00
    		Inhibitor
    LG 82-4-00 is a thromboxane (TX) synthase inhibitor with an IC50 value of 1.1 μM. LG 82-4-00 can inhibit collagen-induced TXB2 formation and platelet aggregation in plasma. LG 82-4-00 can be used in studies related to thrombotic diseases.
    LG 82-4-00
  • HY-113444
    Prostaglandin D3
    		Inhibitor
    Prostaglandin D3 (PGD3) is a prostaglandin that acts as an inhibitor of platelet aggregation and a modulator of autonomic neurotransmission in humans.
    Prostaglandin D3
  • HY-116549
    Prostaglandin F2α alcohol
    		Agonist
    Prostaglandin F2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
    Prostaglandin F2α alcohol
  • HY-142972
    19(S)-HETE
    		Agonist
    19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.
    19(S)-HETE
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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